The one where I explain physical bloat

 FAT! Yes, it is a damned scary word, and it should scare you too, because nobody knows what the hell it is. Fat, lipid count, triglycerides, HDL, cholesterol, LDL, fatty acids, omega-3, saturated and unsaturated...nobody has bothered to really explain what the hell all this meant to me, they are just numbers on a blood panel and plenty of people to tell you how bad some numbers are and how good others are, but no reasons why. 

We'll start with the largest category, lipids. Lipids include all sorts of chemistry, fat, wax, alcohols in the sterol family, and a whole host of others. What we call "fat" is triglyceride. A triglyceride is three fatty acids bound together with something, usually a molecule of glycerol. Glycerol is an interesting compound in itself, having three dangling hydroxyls that allow the attachment of the three fatty acids, which makes triglycerides an ester molecule when fully formed. Glycerol is already hydrophobic, adding three more hydrophobic fatty acids works to make it even more, fatty like, and oily. 

Almost any fatty acid will do to make a triglyceride, you only need three. And there are a bunch of different fatty acids broken up into, broadly, two groups, saturated and unsaturated. So what is saturation to begin with?

In organic chemistry, a molecule is said to be saturated when there are no double bonds in place for all the carbon atoms present. Any space that a double bond can occur is replaced with a hydrogen, so generally the saturation amount of a particular molecule describes how many hydrogens that a particular substance can pick up. Fatty acids are long chains of carbon to begin with, so unsaturated fats are triglycerides which have at least one double bond connecting the carbon atoms together that make up the fatty acids. Monounsaturated fats have one double bond, polyunsaturated fats have more than one double bond. Saturated fatty acids don't have any double bonds at all, they have all been taken up by hydrogen atoms and are connected only by single bonds.

Why the hell would the presence of hydrogen matter? Energy. Unsaturated fats contain less calories, and are easier to break up. Saturated fats are harder to break up and can persist longer, and release more energy (they are bound together with all those hydrogens pretty hard) when they finally get oxidized. Interestingly enough, this is the exact reason hydrogenation is used in oils and fats for foods in the first place. By adding all these hydrogens the chemistry of the fatty acids are changes, making them more resistant to oxidation and by changing the binding properties of the fats and oils themselves. Hydrogenation makes the oils firmer and gives them a higher smoke point, and stay fresh longer because of this resistance to oxidization. So you might think that you would want all your fat to be polyunsaturated, but there is one more problem with fats than just how many hydrogens and double bonds: stereochemistry.

Molecules are described not only by their constituent atoms, but also by how they are put together. Simple molecules like water and salt bind together the exact same way every time, but larger configurations can have multiple arrangements. These different substances, the same in composition, but different in structure, are isomers. There are different kinds of isomers, and just because it may be composed of the same atoms, they may have vastly different reactions because of the shape. In this case, we're concerned with cis-trans isomers, and I can explain trans fatty acids and why everyone is scared of them.

This is oleic acid, found in the fats of olive oil, and is a cis fatty acid.

250px-Oleic-acid-3D-vdW.png

This is elaidic acid, a trans isomer, generated during the hydrogenation process of making cooking oils:


250px-Elaidic-acid-3D-vdW.png

Structurally they look different from one another. They are composed, however, of the exact same number of carbon atoms and have the exact same carboxylic acid at the head. How the double bond at the middle is angled determines whether or not something is considered trans, or cis. The trans molecule, you can see, is straight and symmetrical (at least the aliphatic tail is) while the cis is bent and funny looking. The fact that these geometries exist make a lot of difference in their chemistry.

Trans isomers tend to be a lot more stable than their cis counterparts. This is mostly due to the geometry (how the molecule would fit with itself, for example, when cooling to form a solid could dictate different crystal formations or even change the boiling point) and dipole moment. (when you add up all the individual charges in a molecule, this is expressed as a vector. If the dipole moment is different, then the forces that dictate interactions with other molecules will be different)

Trans fatty acids do occur naturally, but your body doesn't need any of them in any way shape or form. (Some animals make trans fatty acids as a matter of course, but the amount of it in natural foods are quite low) These fatty acids can be metabolized, but since they are in the trans configuration, the enzymes that normally break up fat have a hard time dealing with the trans, probably because we evolved to expect the cis configuration and the lipase simply isn't up to the task of dealing with the rigid and tougher trans geometry.

As a result of this, the trans fatty acids and their attendant triglycerides hang around in the body a lot longer than the others, refusing to be properly metabolized, and ending up in places you didn't want them to be, like arterial walls and contributing to plaque formations. This is the real reason trans fatty acids are bad for you, they just aren't dealt with by the body. Maybe we'll eventually evolve a lipase that can chew through trans acids and heart disease of this sort won't happen anymore, but the safest way of dealing with it is to remove it from the diet altogether. (Bacon fat is never a transfat. Just so you know. It is, however, saturated.)

Now you know what transfats, unsaturated and saturated fats, hydrogenation and all that are. One more thing about fatty acids: what is the omega number? That's easy, it tells you which carbon bond is the first double bond on the fatty acid chain, counting from the tail end. An omega-3 fatty acid has the double bond at the 3rd bond, omega-6 at the sixth bond, and so on. 

So, that's fat, carbon atoms in three chains. Next, i'll explain what role all these triglycerides play in your personal chemistry.